Programme
Scientific Programme
The full scientific programme for the 3rd PNEV Meeting 2025 is now available.
Explore the sessions, keynote talks, oral communications, and poster presentations planned for June 26–27 at the University of Algarve.
Day 1: June 26th
08:30 | REGISTRATION |
8:50 - 9:00 | Opening session |
9:00-9:45 | Plenary Session - "The ins and outs of large extracellular vesicles" - Edit Buzas, Semmelweis University, Hungary; ISEV |
9:45-10:15 | Coffee-Break and Poster Sessions: I - Fundamental biology and pathophysiology
2- EV-driven autofluorescence in retinal pigmented epithelium: photoreceptor debris transfer, proteostasis and AMD pathogenesis, Luís Mourão de Carvalho Ferraz 3- Alternaria alternata extracellular vesicles proteome, Daniela Marques Calheiros 4- Extracellular vesicles as carriers of ATXN2 mRNA: implications for SCA2 progression, Rafael Costa 5- Development of an in vivo model to track and visualize EV secretion using Drosophila, Carolina Alves dos Santos 6- The impact of breast cancer-derived EVs on endothelial cells, Rita Gameiro Menino 7- The impact of Cardiomyocyte-secreted Extracellular Vesicles on cardiac cell function and Atrial Fibrillation progression, Maria Ana Gonçalves II - EVs in cancer 8- Harnessing lactoferrin-loaded extracellular vesicles for colorectal cancer treatment, Débora Ferreira 9- Modelling glioblastoma-brain cell interactions through extracellular vesicles using patient-derived cells and human brain organoids, Cátia Dias Correia 10- Extracellular vesicles released by non-small cell lung cancer multidrug resistant cells identify SRC as a promising molecular target to overcome drug resistance, M. Helena Vasconcelos 11- Unlocking drug resistance in colorectal cancer: The critical role of extracellular vesicles, André Machado da Luz 12- Polyoxometalates and extracellular vesicles in cancer, David Manjua Rijo 13- Prognostic value of urinary extracellular vesicles proteins for biochemical recurrence in prostate cancer, Catarina Cardoso Pires |
10:15 - 11:45 | SESSION I: EVS FUNDAMENTAL BIOLOGY AND PATHOPHYSIOLOGY |
Chair(s): Henrique Girão, UC / Dina Simes, Ualg | |
10:15 – 10:45 | |
10:45 – 11:45 | ORAL PRESENTATIONS Exploring Aβ-driven changes in neuronal-like cells and extracellular vesicles using FTIR Spectroscopy, Margarida Vaz Extracellular vesicles play a role in cardiac cell dysfunction in Hereditary Transthyretin Cardiac Amyloidosis, Ânia Isabel Correia Rodrigues Unravelling the inflammatory properties of extracellular vesicles atherosclerosis: are they mediators of immune response?, André R. A. Marques Exploring the Baculovirus-Insect Cell System for Extracellular Vesicle Production: The Case of Gla-Rich Protein (GRP), Carla Viegas |
11:45 -12:15 | Solmelgas (20 min) ExodusBio (10 min) |
12:15 – 13:45 | Lunch Break |
13:45 – 15:15 | SESSION II: EVS IN CANCER |
Chair(s): Helena Vasconcelos, i3S | Alexandra Fernandes, FCT-NOVA | |
13:45 – 14:15 | |
14:15 – 15:15 | ORAL PRESENTATIONS Targeting miR-155 in triple negative breast cancer via CRISPR/Cas9 delivery using peptide-engineered extracellular vesicles, Débora Carina Gonçalves de Abreu Ferreira Relevance of WNT6 in extracellular vesicles of glioblastoma: clinical and molecular insights, Helena Margarida Rodrigues de Figueiredo Glycosylated EVs in local and distant reprogramming in gastric cancer and its potential for biomarker applications, Daniela Freitas Proteomic analysis of plasma Extracellular Vesicles from gastroesophageal cancer patients: towards the identification of early biomarkers of sarcopenia for surgical risk stratification, Ana Carolina Fernandes Vieira de Castro |
15:15 – 15.45 | Coffee Break and Poster Session III - Translation with EVs: disease, biomarkers, and therapeutics 14- An innovative transdermal heart‑targeted drug delivery strategy based on broccoli extracellular vesicles, Mónica da Rocha Zuzarte 15- BCG immunotherapy response in bladder cancer patients: the value of extracellular vesicles’ miRNAs as predictive biomarkers, Ana Rita Teixeira Marques 16- Neural exosomes loaded with miR‑124 regulate multiple pathological mechanisms in the 5xFAD mouse model of Alzheimer’s disease, Gonçalo Rodrigues Garcia 17- Surface of extracellular vesicles from activated platelets are decorated with coagulation‑associated proteins, Eduarda M. Guerreiro 18- Blood‑derived extracellular vesicles as potential biomarkers for Alzheimer’s disease diagnosis: proteomic and metabolic insights, Tânia Cristina Soares Martins 19- Unveiling dendritic cells‑derived extracellular vesicles as an immunotherapeutic tool in triple‑negative breast cancer, Sofia Torres Ferrando Alves Quintas 20- Plasma processing protocols affect the yield and purity of extracellular vesicles isolated from gastric cancer liquid biopsies, Ana Carolina Fernandes Vieira de Castro 21- Characterization of extracellular vesicles (EVs) in fish seminal and blood plasma with potential use as quality markers, Elsa Cabrita 22- Evaluation of PD‑L1 expression levels and localization in cancer cells and EVs: searching for candidate biomarkers of immunotherapy, Catarina A. Rodrigues 23- Priming the immune system: how Candida albicans extracellular vesicles can influence macrophage responses, Rita Sofia de Jesus Pita Domingues 24- The Role of Polyoxometalates and EVs as Biomarkers and Antioxidants, João Carlos Palminha Mateus 25- Hydrogel-based photonic platforms for detection of extracellular vesicles, Dinarte Neves |
15:45 - 17:15 | SESSION III: TRANSLATION WITH EVS: DISEASE, BIOMARKERS AND THERAPEUTICS |
Chair(s): Lino Ferreira, FMUC / Pedro Batista, FCT-NOVA | |
15:45 – 16:15 | |
16:15 – 17:15 | ORAL PRESENTATIONS Two Systems, One Goal: Optimizing EV Production for GRP Delivery, Joana Sofia Camilo Carreira Gene Disruption and Recombinase-Mediated Gene Integration Facilitated by surface-modified SPARK Extracellular Vesicles, Kevin Costa Leandro From Sleep Apnea to Aging: The Role of Extracellular Vesicles, Bárbara Vicente dos Santos Impact of extracellular vesicles’ co-isolated biomolecules on batch quality and functional assessment, Andreia Machado da Silva |
17:15 – 17:30 | Norleq (10 min) Paralab (5 min) |
17:30 – 19:00 | General Meeting of all PNEV members |
20:30 | Meeting networking dinner(upon prior confirmation) Location: EVA Senses Hotel - Faro |
Day 2: June 27th
9:00-10.30 | SESSION IV: EVS IN IMMUNITY, TISSUE REPAIR, AND METABOLIC PROCESSES |
Chair(s): Anabela Cordeiro da Silva, i3S | Susana Santos, i3S | |
9:00 – 9:30 | |
9:30-10:30 | ORAL PRESENTATIONS Extracellular Vesicle-Mediated Endothelial Dysfunction in Heart Failure with Preserved Ejection Fraction: Unraveling the S100A9-TLR4 Signaling Axis, Elsa Daniela Costa Silva Dendritic Cell Extracellular Vesicles Meet Fibrinogen Scaffolds: A Synergistic Route to Bone Regeneration, Joana Filipa Pereira Coelho Mesenchymal stem cell-derived small extracellular vesicles promote liver regeneration after APAP injury in vitroand in vivo, Ana Sofia Martins Serras A151-loaded Small Extracellular Vesicles from 3D MSC Cultures Boosts Immunomodulation in Ulcerative Colitis, Sérgio José Póvoas Camões |
10:30-11:00 | Coffee-break and Poster Sessions IV - EVs in immunity, tissue repair, and metabolic processes 26- Cyanobacterial extracellular vesicles as protein carriers: towards fish vaccination, Jorge Matinha Cardoso 27- Are extracellular vesicles involved in starfish arm regeneration?, Ana Varela Coelho 28- The role of epicardial fat stem cell derived extracellular vesicles in cardiac regeneration after ischemia/reperfusion injury, Marcelo Vilas Boas 29- IFN-gamma preconditioning alters the molecular signature profile of sEVs involved in neuroregeneration and immunomodulation, Catarina Marçal de Sousa V - EVCA, an Extracellular Vesicles Consortium 30- Extracellular vesicles in obesity: the liver-muscle compensatory axis, Rita Machado de Oliveira 31- Investigating BIN1-Mediated Tau Propagation via Extracellular Vesicles in Alzheimer's Disease, Ana Rafaela Fernandes 32- Decoding Extracellular Vesicles in Peritoneal Dialysis, Diogo André Sequeira 33- Tumor-Derived Extracellular Vesicles in DLBCL: Impacts on PBMC Function and Prospects for Personalized Therapy, Anastasiia Subach 34- Enhancing Extracellular Vesicle Characterization through High-Resolution Mass Spectrometry: Development of an R Package and Testing with Public Plasma Datasets, Rune Matthiesen 35- Cardiac signaling via EVs derived from CCBE1 human cardioids in response to cardiac injury, Carlos Nunes Vital 36- Extracellular Vesicles in diabetic retinopathy: the gut-retina axis, Luana Macedo |
11:00 – 12:30 | SESSION V: EVCA, an Extracellular Vesicles Consortium (UNL_NMS, I. Curie and CIC bioGUNE) |
Chair(s): Rune Matthiesen (EVCA Coordinator) and Paulo Pereira (INOVA4health and EVCA Coordinator) | |
11:00 – 11:30 | |
11.30 – 12:30 | ORAL PRESENTATIONS Pleural effusion-derived extracellular vesicles in malignant disease, Ana Sofia Carvalho Defining Exosomal Specificity: LAMP2A-Mediated Protein Loading and Its Impact on Endosomal Dynamics, João Vasco Oliveira Ferreira Size Exclusion Chromatography enables purification and cleaning of EV formulations for clinical applications, Esperanza González The arginine methyltransferase CARM1 associates with and methylates ALIX, an accessory protein of the ESCRT machinery, Thierry Dubois |
12:30 – 12:45 | Everest Biolab (10 min) |
12:45– 13:15 | Prizes for best selected oral presentations and posters and closing session |